2 edition of Effect of estrogen on angiogenic factor expression in cultured uterine cells. found in the catalog.
Effect of estrogen on angiogenic factor expression in cultured uterine cells.
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Ischemic cardiomyopathy is a leading cause of mortality in North America. Although advances in current treatments have been significant in improving myocardial perfusion, many patients still cannot be treated properly. Thus, new therapies need to be developed. Since angiogenesis occurs naturally in the female reproductive tract, the cells from the uterine tissue may be ideal candidate cells to induce angiogenesis, which could be further enhanced through estrogen stimulation. My in vitro dose-response and time course demonstrated that estrogen did not regulate vascular endothelial growth factor (VEGF) protein levels in cultured uterine cells. However, an in vivo study demonstrated that transplantation of cells with or without estrogen increased blood vessel formation. The data suggests that signals mediated by cells and/or estrogen may induce larger vessel formation.
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Apr 26, · The angiogenic peptide adrenomedullin (ADM) has been implicated as a mediator of the increased risk of endometrial hyperplasia and cancer resulting from the use of tamoxifen for the treatment and prevention of breast shareholderdemocracy.com by: Objective. To determine tissue concentrations of E 2, estrone, P, and estrogens metabolites (EMs) 2-methoxyestradiol, 2-methoxyestrone, 4-hydroxyestrone, and ketoestradiol in corpus luteum (CL) of different ages, and after hCG administration; and to examine the effects of EMs on vascular endothelial growth factor (VEGF) secretion and angiogenic activity released by cultured luteinizing Cited by:
Vascular endothelial growth factor (VEGF) is a potent angiogenic and prognostic factor for many tumors, including those of endocrine-responsive tissues such as the breast and uterus. Recent studies indi-cate that 17 -estradiol (E2) modulates VEGF expression in breast and uterine cells, involving transcriptional activation through estrogenCited by: Jan 01, · It is well known that many diseases and pharmaceutical compounds may influence the menstrual cycle and the endometrium. It has been shown that uterine pathology can cause an abnormal expression of different angiogenic growth factors and growth factor receptors (Kooy et al., ; Anania et al., ; Sangha et al., ).Cited by:
Dec 30, · Studies show that E2, through its receptors, either on uterine cells or uterine endothelium has rather promoting effect on angiogenesis, causing increased VEGFA and VEGFR2 expression [37, 38]. There is less studies concerning the localisation and expression of oestrogen receptors in endothelial cells in ruminant uterus [ 2 ].Author: Martyna Lupicka, Anna Zadroga, Agata Szczepańska, Anna Justyna Korzekwa. Jan 01, · Whereas the exact effects of estrogen appear to be context-dependent, our results provide concrete evidence that —besides the stimulatory effect on the expression of pro-angiogenic regulators such as VEGF—estrogen may also function on alternative targets such as the antiangiogenic factor Cited by: 8.
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Oct 01, · On the basis of the results of the current study and of other in vitro and in vivo studies, we suggest that estrogen, by regulating expression and secretion of angiogenic factors such as VEGF by glandular epithelial cells of the endometrium, regulates endometrial microvascular endothelial cell tube formation and thus shareholderdemocracy.com by: We propose that estrogen, by regulating expression and secretion of angiogenic factors such as VEGF by glandular epithelial cells of the endometrium, regulates endometrial angiogenesis.
Do you. Although VEGF‐A can be detected in the decidual stroma, VEGF‐A production by uNK cells is minimal. VEGF‐A is the best‐characterized, angiogenic growth factor with major effects on endothelial cell proliferation and motility, as well as inducing vascular shareholderdemocracy.com by: Estrogen Receptor ER alpha and beta stimulation by Estrogen increases Vascular Endothelial Growth Factor secretion by Uterine Artery Endothelial.
Dec 23, · The effects of local estrogen on connective tissue components, however, have been less well characterized. The purpose of this study was to use the rat as an animal model to compare the effects of systemic and local estrogen treatment on collagen content and expression of proteins involved in collagen assembly in the vaginal shareholderdemocracy.com by: In line with this issue, early studies showed that, estrogen induces the expression of vascular endothelial growth factor in ovaries and uterine tissue (18, 38).
Thus, we can conclude that PGN. Aug 22, · The NK cells are the principal immune cells present during the WOI and are important for immune tolerance, angiogenesis, trophoblast migration, and invasion. 68 The NK cells produce pro-angiogenic factors such as VEGF and placental growth factor, which regulate maternal–uterine vasculature remodeling and trophoblast invasion.
69,70 Mice Cited by: 7. Estrogen produces its effects by binding to estrogen recep-tors (ER) in the reproductive organs. It has been reported that estradiol increases the extracellular levels of VEGF in breast cancer in vivo, which suggest that VEGF expression in the breast is, at least in part, modulated by ER for which the VEGF gene is a target (7).
In cultured human endometrial fibro. The effect of monocyte conditioned medium on estrogen and progesterone regulation of gene expression in cultured endometrial stromal cells Article in Fertility and Sterility 88(1) · September.
Regulation of Angiogenic Activity of Human Endometrial Endothelial Cells in Culture by Ovarian Steroids Article (PDF Available) in Journal of Clinical Endocrinology & Metabolism 89(11) To investigate the effects of estrogen replacement therapy (ERT) on apoptosis and vascular endothelial growth factor (VEGF) expression in ocular surface in an experimental rat shareholderdemocracy.com female, Wistar rats were randomized in 4 groups in the study.
Subcutaneous Cited by: 5. We proposed that estrogen promotes endometrial angiogenesis by regulating VEGF expression by glandular epithelial and stromal cells.
In the present study, we developed a co-culture of human endometrial cells and microvascular endothelial cells to determine whether the regulatory role shown for estrogen on endometrial angiogenesis in vivo in the non-human primate would be demonstrable.
Effect of estrogens on skin aging and the potential role of SERMs conversely it stimulates proliferation of uterine cells by acting as an estrogen Haczynski J, Tarkowski R, Jarzabek K, et al.
Differential effects of estradiol, raloxifene and tamoxifen on estrogen receptor expression in cultured human skin fibroblasts. Int J Mol Med Cited by: Because angiogenic growth factors such as basic fibroblast growth factor (bFGF), vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) are increased in pregnancy, we hypothesized that treatment of uterine and fetoplacental arteries with bFGF, VEGF, and EGF would further enhance the pregnancy-induced increase in PGI 2 production.
Duplicate uterine (UA) and Cited by: transforming growth factor-b, and an Mr 18, leiomyoma-derived mitogenic protein (8–14). bFGF shows a mitogenic effect on cultured leiomyoma cells (15). Other growth factors such as the peptide ADM and the angiogenic enzyme TP have been identified in uterine tissues but not systematically studied in leiomyomas (16–19).Cited by: Dissecting the role of dNK cells is complex because of the number of cytokines and angiogenic factors produced by these cells, some of which can have opposing effects, as evidenced by the inhibition of tube formation by endostatin and promotion by shareholderdemocracy.com by: Jun 01, · These observations suggest that the growth factor could exert effects in the uterus throughout the entire lifespan of mammals.
expression of angiogenic factors. Sex steroids and growth factors differentially regulate the growth and differentiation of cultured human endometrial stromal shareholderdemocracy.com by: Nov 01, · Furthermore, uterine expression of proangiogenic factors is very low on d 1 of pregnancy in mice when the uterus is under the dominance of preovulatory ovarian E secretion.
However, dramatic increases in the expression of these factors are observed from d 4 onward, with rising P 4 levels by the newly formed corpora lutea (2, 4).Cited by: Sep 25, · Estrogen-dependent Production of Erythropoietin in Uterus and Its Angiogenic activity of Epo has been studied by the use of in vitro cultured endothelial cells.
us to examine the role of Epo in the E 2-induced endometrial regeneration with an expectation that Epo acts as a uterine angiogenic factor. Previous Section Cited by: Overexpression of estrogen receptor-α in the endometrial carcinoma cell line Ishikawa: inhibition of growth and angiogenic factors Author links open overlay panel Syed Hamid Ali a Amy L.
O'Donnell a c Seema Mohamed d Shaker Mousa d Paresh Dandona a bCited by:. Abstract. Progressive tumor growth has been associated with neovascularization induced by an angiogenic factor(s) that the tumor secretes (1).
Therefore, inhibition of neovascularization could be effective in suppressing tumor growth (2). The antiproliferative effects of progestins in human endometrial cancer cells have been demonstrated by several Author: Naoki Terakawa.Effects of estradiolβ on expression of mRNA for seven angiogenic factors and their receptors in the endometrium of ovariectomized (OVX) ewes Article in Endocrine 30(3) · January Induction of the angiogenic factor VEGF in the uterus by the antiprogestin onapristone In their studies administration of the antiprogestin for 24–72 h produced several estrogen-like effects including an increase in PR and ER M.Y.
DawoodThe expression of vascular endothelial growth factor isoforms in cultured human endometrial stromal Cited by: 8.